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L-Theanine Dosage for Anxiety


According to the Anxiety and Depression Association of America, anxiety disorders are the most common mental illnesses in the U.S., affecting 40 million adults, or 18.1% of the population, every year.

The National Institute of Mental Health further substantiates the prevalence of anxiety disorders, stating that an estimated 19.1% of U.S. adults had any anxiety disorder in the past year. Furthermore, it is significant to note that an estimated 31.1% of U.S. adults experience any anxiety disorder at some point in their lives. Anxiety disorders are highly treatable, yet only about one-third of those suffering receive treatment.

L-theanine, an amino acid commonly found in green tea, has gained popularity as a natural supplement for its potential to help with anxiety and stress management. In this article, we will discuss the recommended L-theanine dosage for anxiety relief.


Key Takeaways

  • L-theanine, a unique amino acid found in green tea and bay boletus mushrooms, has been studied for its ability to promote calmness, reduce insomnia, and alleviate stress and anxiety. It crosses the blood-brain barrier and affects the brain directly within 30 minutes.
  • L-theanine has shown promising results in helping reduce anxiety and depression symptoms. It increases alpha brain wave activity, relaxes the mind without causing drowsiness, and raises levels of neurotransmitters responsible for mood regulation. It also has neuroprotective effects and can inhibit cortical neuron excitation.
  • The recommended dosage of L-theanine for anxiety is between 50 and 200 mg, with effects lasting for 8 to 10 hours. Starting with a dose of 50-100 mg and gradually increasing it to 400 mg can be effective. It is generally well-tolerated, but potential interactions with certain medications should be considered.
  • Pregnant and breastfeeding individuals should avoid L-theanine due to insufficient information on its safety. Consultation with a healthcare professional is recommended for personalized dosage recommendations.


Understanding L-Theanine

L-theanine is a unique amino acid predominantly found in green tea leaves, though it's also present in some mushrooms. This compound is the key to that distinctive, savory flavor you experience when you sip your green tea. 

However, L-theanine does more than just contribute to the taste. It has an impressive impact on your brain, inducing a calming effect that can help manage anxiety.

Upon ingestion, L-theanine has the ability to cross the blood-brain barrier within roughly 30 minutes. This swift action allows it to directly influence brain functions. One of its key effects is on alpha brain wave activity. 

An increase in these waves is usually associated with a state of wakeful relaxation, the kind of serene alertness you feel during meditation.

Interestingly, L-theanine doesn't just relax you. It also affects your mood by influencing the release of neurotransmitters such as dopamine and serotonin in your brain. These are the chemicals that regulate your emotions and overall mood.

Sources of L-Theanine

Below are some of the most common sources of L-theanine:

  • Green Tea: Green tea, derived from the Camellia sinensis plant, is a rich source of L-theanine. This beverage, widely consumed in Asian countries, is renowned for its calming effects, which are attributed to its high L-theanine content. The presence of this amino acid is what gives green tea its unique umami flavor.
  • Black Tea: Black tea, another product of the Camellia sinensis plant, also contains L-theanine, albeit in lesser quantities than green tea due to the fermentation process it undergoes. Despite this, it remains a beneficial source of L-theanine, and its deeper, more robust flavor makes it a popular choice for many tea drinkers.
  • Bay Bolete Mushrooms: In addition to tea leaves, certain types of mushrooms, like the Bay Bolete, are known to contain L-theanine. This variety of mushrooms, common in Europe and North America, is not only valued for its culinary use but also for its LtTheanine content. However, the amount present in these mushrooms is significantly less than that found in tea leaves.

Potential Benefits of L-Theanine

Below are some of the studied potential benefits of L-theanine:

Increased Focus

The reason why the best brain performance supplements contain L-theanine is that it has been shown to support focus and concentration.

When paired with caffeine, L-theanine may potentially enhance focus and attention. A small study conducted on a group of young adults found that a combination of L-theanine (97 milligrams) and caffeine (40 mg) helped them to better focus during demanding tasks.

For context, a typical cup of coffee contains about 95 mg of caffeine. Additionally, the study participants reported feeling more alert and less fatigued in general. This suggests that the combination of L-theanine and caffeine may have synergistic effects in promoting alertness and reducing tiredness.

Improved Immunity

Immunity improvement is another potential benefit of L-theanine. Based on research, your body's immune system may function better with L-theanine. A study published in the Beverages Journal associated L-theanine with a decrease in upper respiratory tract infections.

Another study found that the combination of green tea catechins (antioxidants) and L-theanine could possibly prevent the flu. It's important to note that these findings require further research for confirmation and broader understanding. This information could be crucial for your decision-making.

Blood Pressure Regulation

If you're prone to high blood pressure during moments of stress, L-theanine might provide some relief. A recent study discovered a positive correlation between L-theanine consumption and lowered blood pressure.

Individuals who typically experienced increased pressure readings reported a noticeable reduction after taking L-theanine. Interestingly, the study also highlighted that caffeine had a somewhat similar effect, but the benefits were less substantial. 

This finding could be a significant factor in your decision-making process, especially if you're seeking natural alternatives to manage stress-induced high blood pressure.


L-Theanine for Anxiety and Depression

Unfortunately, at some point in our lives, we go through difficult times. Sometimes a disturbing event can make us feel depressed or anxious.

Depression is a severe mood disorder that affects how you feel, think, and act. Activities that you once enjoyed are no longer exciting, and a feeling of sadness seems to be here to stay. 

This disorder affects more than 300 million people worldwide. According to the World Health Organization (WHO), it is the leading cause of disability and the second most common psychiatric disease after anxiety, an intense feeling of fear or apprehension about what’s to come that interferes with your everyday life.

This last one is the most typical emotional disorder that influences people of all ages and genders. In fact, 1 in 5 people is affected by one or both diseases.

Psychiatrists treat anxiety and depression with antidepressants, but these drugs can often have serious side effects. For this reason, more and more people are starting to look into alternative treatments. L-theanine might be the natural supplement you’re looking for to combat the symptoms of both conditions safely. 

This non-proteinaceous amino acid, primarily found in green tea, is popular in Asian countries for its anxiolytic effects. Besides modulating aspects of the function of our brains, it also has several health benefits, including mood improvement, cognition, and reduction of anxiety-like symptoms.

Early research shows that taking L-theanine orally at bedtime for eight weeks could decrease symptoms and improve sleep in people with depression. However, it takes more than a cup of black or green tea to achieve this calm state of mind.

This effect only appears with higher doses. If you’re interested in learning how much L-theanine to take for anxiety, keep reading below.


Does L-Theanine Work for Anxiety?

Anxiety and depression are global challenges affecting millions. The World Health Organization reports that over 300 million people grapple with anxiety disorders, while more than 280 million people live with depression. 

These mental health conditions have a profound impact on the quality of life, often leading to decreased productivity, disrupted relationships, and even serious physical health problems.

Traditional treatments for these disorders typically involve a combination of therapy and medication. However, these treatments are not without their drawbacks. Antidepressants, for example, can come with undesirable side effects like insomnia, weight gain, and sexual dysfunction. 

Moreover, they don't always work for everyone, and some people may find themselves searching for alternative solutions.

L-theanine is an amino acid that has been found to help alleviate symptoms of both anxiety and depression. It does this by boosting GABA levels in the brain, promoting a calming effect that can help manage anxiety.

Moreover, research has shown that it may even help improve other symptoms associated with mental health conditions, such as schizophrenia. If you're looking for a natural and safe alternative for managing anxiety and depression, L-theanine could be a viable option to consider. Its potential benefits, coupled with its low risk of side effects, make it an attractive solution for many.

How Does L-Theanine Work for Anxiety?

The best adaptogens for anxiety and stress contain L-theanine as an essential ingredient. This is because this amino acid is known to cross the blood-brain barrier, which means it can impact brain activity.

L-theanine works by increasing GABA (gamma-aminobutyric acid) levels in the brain. GABA is an inhibitory neurotransmitter responsible for calming neurons and reducing anxiety.

In a comprehensive review of five trial studies involving 104 participants, it was noted that four trials linked L-theanine with reduced stress and anxiety. This connection was particularly evident in those who were under stress.

A separate study published in the Journal of Clinical Psychiatry explored the effects of L-theanine in individuals living with schizophrenia or schizoaffective disorder. The researchers found that L-theanine not only helped to alleviate anxiety but also improved other symptoms associated with these conditions.

L-Theanine and Alpha Brain Wave Activity

Numerous human electroencephalogram (EEG) studies have provided compelling evidence of L-theanine's impact on brain wave activity. Notably, L-theanine has been found to increase alpha brain wave activity, a type of brain wave associated with a state of "wakeful relaxation." This is the state your brain is in when you are relaxed and alert, like during meditation or when you are in a flow state.

A study demonstrated that individuals who took L-theanine exhibited increased alpha brain wave activity compared to a placebo group. This increased alpha brain wave activity signifies a state of relaxed alertness, enhancing overall mental focus and cognitive performance.

Calming Effects without Drowsiness

A unique aspect of L-theanine is its ability to promote relaxation and reduce stress without inducing drowsiness - a common side effect associated with many anti-anxiety medications. It provides a calming effect that doesn't interfere with cognitive function or lead to impaired concentration. 

L-theanine promotes relaxation by boosting levels of GABA, serotonin, and dopamine neurotransmitters which influence emotions, mood, concentration, alertness, energy, and sleep.

L-Theanine for Stress Reduction

A study published in the Journal of Nutrition & Intermediary Metabolism found that supplementation with L-theanine led to a significant reduction in stress among participants. Participants who took L-theanine displayed not only lowered stress responses but also improved cognitive function during tasks requiring high attention. 

Thus, L-theanine could potentially be an effective natural remedy for stress and anxiety, enhancing day-to-day productivity and well-being.

L-Theanine's Brain-Blood Barrier Breakthrough

L-theanine acts with a unique mechanism, allowing it to effectively cross your blood-brain barrier. This is the protective layer that acts as a gatekeeper, deciding which substances reach your brain. L-theanine is one of the few compounds capable of gaining access. 

Once inside the brain, this amino acid starts working its magic, interacting with your neurotransmitters.

It primarily influences three neurotransmitters: GABA, serotonin, and dopamine, which are crucial for emotions, mood, concentration, alertness, energy, and sleep. L-theanine elevates the levels of these neurotransmitters, promoting a state of calm, enhancing cognitive performance, and reducing stress responses.

L-theanine also serves a neuroprotective role. It shields your brain cells from oxidative stress and damage. This neuroprotection contributes to the preservation of cognitive function, particularly in stressful situations. 

Stress hormones can destabilize cognitive function, but with L-theanine's influence, your mental performance remains undisturbed.

So, if you're considering L-theanine for anxiety, it's worth noting that it works in multiple ways, not only enhancing your brain's resistance to stress but also promoting relaxation, improving cognitive function, and protecting your brain health.


How Much L-Theanine Should I Take for Anxiety?

Studies have shown that 200 mg of L-theanine may help reduce resting heart rate, indicating its ability to promote relaxation. While some academic works suggest that this natural compound may hold the key to improved mental health, it’s crucial to notice that some results in clinical research studies are inconsistent.

When compared to the prescription medication alprazolam (1 mg),  there are non-significant anxiety-reducing effects.

On the bright side, L-theanine is usually well tolerated. Currently, there are no published reports of severe adverse side effects. Rarely, headaches and facial tics may appear.

Furthermore, unlike benzodiazepines, this naturally occurring amino acid does not lead to tolerance and dependence when used over long periods.

There are no interactions with other natural products or conventional prescription medications except for antihypertensive (may potentiate its activity) and stimulant drugs (may decrease its effects) such as:

  • Captopril (Capoten)
  • Enalapril (Vasotec)
  • Losartan (Cozaar)
  • Valsartan (Diovan)
  • Diltiazem (Cardizem)
  • Amlodipine (Norvasc)
  • Hydrochlorothiazide (HydroDiuril)
  • Furosemide (Lasix)
  • Diethylpropion (Tenuate)
  • Epinephrine
  • Phentermine (Ionamin)
  • Pseudoephedrine (Sudafed)

Best Dose of L-Theanine for Anxiety

Although there’s currently no official theanine dosage guideline in the United States, studies have shown that doses between 50 and 200 mg of L-theanine are needed to enhance alpha brain wave activity. 

You will experience the calming effects of this compound 30 minutes after ingestion, and it may last within 8 to 10 hours. 

If you're considering taking L-theanine for anxiety, we recommend beginning with a dose between 50-100 mg. Then, you can gradually increase it to 400 mg.

Moreover, in combination with 30-100 mg caffeine, L-theanine (12.5-100 mg) may  improve visual information processing, reduce mental fatigue, increase reaction time and working memory, alertness, and ease headaches. 

Due to the insufficient information about the use of Theanine during pregnancy and breastfeeding, we recommend avoiding its consumption for safety. 


L-Theanine Dosage for Anxiety

In the United States, there isn't an official guideline for L-theanine dosage. However, for anxiety, a range of 50-200 mg per day is often recommended. The effects of L-theanine tend to last between 8-10 hours, providing potential relief throughout the majority of your waking hours.

If you're considering introducing L-theanine into your routine, start at the lower end of that range, with a dosage of 50-100 mg. This allows your body to gradually adapt to the substance. 

If you're not experiencing the desired effects after a period of consistent use, you could slowly increase your intake. Some individuals find that a dosage of up to 400 mg is needed to experience the full range of benefits.

However, it's important to note that L-theanine is generally well tolerated, but like any supplement, it can interact with certain medications. Therefore, it's always a good idea to consult with your doctor or a healthcare professional before starting a new supplement regimen.

Clinical research on the effects of L-theanine, particularly on anxiety, has presented somewhat inconsistent results. Some studies show significant stress reduction, while others show more modest benefits. This is why it's crucial to consider your unique body chemistry and personal response when determining the best dosage for you. 

Remember, what works for one person might not work for another, so it's key to monitor your response and adjust your dosage as needed.

L-Theanine Dosage Guidelines for Special Cases

If you're pregnant or breastfeeding, it's best to err on the side of caution and avoid taking L-theanine. The safety of L-theanine during these stages is yet to be thoroughly investigated, making it a risk not worth taking. Instead, seek alternative ways to manage your anxiety - activities like yoga, meditation, or controlled breathing can be beneficial.

Regardless of your current health status, the most reliable way to determine your L-theanine dosage is through consultation with a healthcare professional. They can provide personalized recommendations, taking into account your overall health, stress levels, and unique biochemistry. 

Remember, the goal is to enhance your wellness, and the dose needed for that varies significantly among individuals.

Your healthcare provider can monitor your response to the supplement and adjust the dosage as required. This approach prevents any unforeseen interactions with other medications you might be taking and ensures you're not exceeding a safe level of intake. 

So, before diving into a new supplement regimen, take the time to consult a healthcare professional to guide you on your journey to improved mental health.

Interactions and Precautions

L-theanine, though considered safe, may interact with certain medications. If you're taking antihypertensive drugs to manage high blood pressure, be aware. L-theanine has a calming effect and may naturally lower your blood pressure. Used together, they may excessively drop your blood pressure levels.

It's a similar case with stimulant drugs; the calming effect of L-theanine might counteract the stimulative effect of these drugs, reducing their efficacy.

L-theanine may also lead to several side effects, including:

  • Dizziness
  • Headaches
  • Nausea
  • Irritability
  • Diarrhea
  • Stomach upset

Note that these side effects are rare, and the majority of users experience little to no adverse reactions.

The good news is that, unlike benzodiazepines commonly prescribed for anxiety, L-theanine does not lead to tolerance or dependence. There's no escalating need for higher doses over time, a concern often associated with benzodiazepines. 

However, as with all health decisions, it's best to approach L-theanine supplementation with careful thought.

Remember to consult a healthcare professional before taking L-theanine, especially if you're on prescribed medications. They can help you navigate potential interactions and guide you on how to incorporate L-theanine into your wellness routine safely and effectively. 

Regular check-ins with your healthcare provider can ensure your chosen approach is working optimally for your unique needs.


Final Words

L-theanine works by decreasing “excitatory” brain chemicals that contribute to stress and anxiety while increasing brain chemicals that encourage a sense of calm and promote cognition and selective attention. 

Research has proved that this non-protein amino acid is generally well-tolerated and has no severe side effects. Nonetheless, these promising findings need to be confirmed. Because there isn't conclusive research, it’s best to consult your medical provider which is the best L-theanine dosage for you before taking any supplement. 


L-Theanine Dosage for Anxiety: Frequently Asked Questions

How Quickly Does L-Theanine Work for Anxiety?

L-theanine generally starts working within 30 to 40 minutes after ingestion. Its calming effects can last between 8 to 10 hours. However, remember that everyone's body is unique and reacts differently.

Can L-Theanine be Taken with Other Anxiety Medications?

Consult with your healthcare provider before combining L-theanine with other anxiety medications. They can guide you on potential interactions and help you determine the safest approach.

Is it Safe to Take L-Theanine Daily for Anxiety?

Yes, it's safe for most people to take L-theanine daily. Regular use can help manage anxiety symptoms, but it's crucial to follow your healthcare professional's recommended dosage.

What are the Known Side Effects of L-Theanine?

Side effects of L-theanine are typically mild and may include headaches, dizziness, and upset stomach. If you experience these or any other side effects, consult your healthcare provider.

Is L-Theanine Safe for Long-Term Use?

Long-term use of L-theanine is generally considered safe. However, as with any supplement, it's best to use it under the guidance of a healthcare professional who can monitor your response.

Are There Any Age Restrictions for L-Theanine Use?

L-theanine is typically safe for adults and older teenagers. However, the safety for children or adolescents is less clear. Always consult a healthcare provider before starting a new supplement.

VYU Blog Disclaimer

The information provided on the VYU blog is intended solely for informational and entertainment purposes. It should not be used as a substitute for professional medical advice, diagnosis, or treatment.

Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment and before undertaking a new healthcare regimen. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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