MNM Supplement Benefits

NMN or nicotinamide mononucleotide supplements are becoming all the rage, and for good reason, because they have a plethora of potential health benefits for the human mind and body.

Although this is a molecule made naturally in the human body, there isn't that much of it present, which is why people have been turning to NMN supplements.

Today, we’re going to find out exactly what the main benefits of NMN supplements might be, how NMN works according to the most recent research, and why these supplements are becoming so popular.

Key Takeaways

• NMN is a naturally occurring molecule in the human body, one that can also be found in supplement format.
• According to recent research, NMN has the ability to provide the human body and brain with a wide variety of benefits.
• This article will discuss exactly what these benefits are, how much NMN you should take, and how safe it is.
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What is an NMN Supplement Good For?

NMN, often shortened as MNM, is a molecule that occurs naturally in the human body and in every living cell in all life forms. It belongs to a special class of molecules known as nucleotides, which are the building blocks for DNA and RNA.

The molecular structure of NMN features three main chemical groups: a nicotinamide base, a ribose sugar, and a phosphate group.

Through various processes in the body, NMN is converted into what is known as NAD+, or nicotinamide adenine dinucleotide. For this reason, NMN is often referred to as an NAD+ booster.

As you might be able to tell, it’s NAD+ that we are also interested in here. NAD+ is an important substance the body requires to function and is the most abundant molecule after water.

Many of the biological functions in the human body require NAD+ to function, mainly to allow enzymes to create chemical reactions.

NAD+ itself is related to various important aspects of human health, with age or age-related decline being one of them.

Our body’s levels of this special molecule decline with age and can also decline as a result of neurodegenerative diseases, cardiovascular disease, age-related muscle wasting, obesity, and more.

Therefore, taking an NMN as a supplement could help increase overall NAD+ levels, helping to mitigate the various negative effects of chronic diseases and aging. 

In other words, this supplement could have potential anti-aging benefits that effectively keep you looking younger for longer by affecting the way in which your cells grow and heal. 

Try to stay with us because things only get more complicated from here on out, but we'll try to keep it as simple as possible!

In essence, supplementing with NMN helps to increase NAD+ levels in the body, as NMN is the precursor to NAD+, and it turns into NAD+. 

According to studies, the administration of NMN “increases mitochondrial NAD+ pools and drives the reduction of mitochondria generated ROS via a SIRT3 dependent deacetylation and stimulation of SOD2 activity. As a result, fission is less active due to decreased binding of pDrp1 (S616) to the mitochondrial outer membrane”.

To make sense of this, you need to know what mitochondria are. Technically speaking, mitochondria are membrane-bound cell organelles.

The mitochondria in our bodies generate the energy that our cells need to perform biochemical reactions, such as healing, growth, and multiplication.

Mitochondria are also responsible for cellular metabolic activity, cell growth, and cell multiplication.

Therefore, if NMN increases NAD+ levels, and if NAD+ helps to increase the function and efficacy of mitochondria, NMN supplementation could potentially improve cellular multiplication and cellular growth.

On that note, if NMN helps to increase cellular metabolism, this also means that it can help increase our overall metabolic rates.

If we have a higher metabolic rate, it means that we get more energy from the food we consume while also burning more calories in a shorter period of time.

Thus, this means that NMN supplementation should help increase our metabolisms, making us feel more energetic while also burning more calories, and acting as a weight loss or weight maintenance supplement.

The simple reality here is that NMN has many different potential effects, with increased energy levels, higher metabolic rates, and improved physical performance being just some of them. 

However, as you'll see further below, and as is backed up by research, this molecule also has the ability to provide you with neurological and cognitive health benefits, many physical performance advantages, and weight management, and it may even be able to slow down the aging process.

NMN and Cellular Health: A Vital Connection

To sum up the above section, NMN supplementation helps to increase NAD+ levels and mitochondrial function.

If our mitochondria function better, it means that our bodies convert more energy into fuel, or in other words, burn more calories. One of the results here is that our higher metabolic rates provide us with more energy while also allowing for better weight management and weight loss benefits.

However, there's more to it than that because, as we also mentioned above, mitochondria are responsible for cell growth, multiplication, and repair.

So, let’s talk about how our mitochondria affect aging. According to research, with age, mitochondria accumulate what is known as ROS-induced damage and eventually become dysfunctional.

If our mitochondria become dysfunctional, it means that our cells have a decreased ability to grow, multiply, and heal, which is directly related to an overall decline in physical health.

For instance, if the cells in our organs can't keep repairing themselves, growing, and multiplying, then our organs start to shut down. Because our mitochondria become less functional with age, it also means that our organs start to decline in health with age. 

The belief is that supplementing with NMN helps to increase NAD+ levels, which in turn helps to increase mitochondrial numbers and functionality, and might help to prevent age-related decline, specifically related to organs, as well as cardiovascular disease, neurodegenerative disorders, and more.

Research shows that mitochondrial decline is directly related to age-related organ decline and that NMN has the potential to slow down or even reverse the process of skin aging.

What it really comes down to here is that NMN has the ability to affect our mitochondria in such a way that increases the ability of our bodies, our cells, to repair themselves and multiply, therefore combating age-related decline.

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The Multifaceted Health Benefits of NMN Supplements

Now comes the main part of our piece, where we talk about the multifaceted health benefits of NMN supplements. If this type of supplement has the ability to help our cells multiply faster, grow faster, and repair themselves, then it should also have many other benefits besides potentially prolonging our lifespans.

We've already included about a dozen studies above that show how the link between NMN, NAD+, and our mitochondria is very real and that it all comes together to provide us with anti-aging benefits. 

However, there's still much more to it than that.

Boosting Brain Function: Neurological Health Benefits of NMN

One of the biggest potential benefits of NMN is the reduction in age-related neurological and cognitive decline. As we age, circulation starts to become fairly poor, and this impaired blood flow to the brain often leads to cognitive impairments.

These cognitive impairments can include issues such as trouble remembering, problems with learning, and various other age-related cognitive impairments.

Simply put, as we age, a lack of blood flow causes our brain to not work as well as it once did. There are many different factors to consider here.

First, the supplementation of NMN has been shown to produce cognitive improvements in rodents suffering from Alzheimer's disease, while also reducing brain plaques and neurodegeneration in mice with Alzheimer's disease. 

Here we have a study that states that “Nicotinamide mononucleotide (NMN), one of the precursors for nicotinamide adenine dinucleotide (NAD+) synthesis, reduces the brain features of AD, including neuroinflammation, mitochondrial abnormalities, synaptic dysfunction, and cognitive impairment.” In other words, this study states that NMN can directly slow down or even reverse the effects of Alzheimer's disease.

Alzheimer's aside, if we are just talking about regular age-related cognitive decline, seeing as this is generally caused by a lack of blood flow and circulation to the brain, then increasing blood flow to the brain should also help prevent age-related cognitive decline. 

Well, here is a study that suggests that NMN may have the ability to increase circulation to the brain, which should, therefore, also help prevent age-related cognitive decline, particularly related to memory and learning.

There are even strong indications that NMN supplementation may help prevent the blood vessels in the brain from becoming clogged, therefore preventing strokes from occurring. 

Energy and Endurance: Physical Performance Advantages

As we’ve already discussed above in great detail, NMN is closely linked to energy metabolism thanks to the way in which it affects mitochondria. Just to jog your memory, NMN helps to improve mitochondrial function, which in turn helps to improve overall metabolism.

Your metabolism determines how many calories you burn in a given amount of time.

The higher your metabolism, the more calories you burn. Furthermore, calories are your fuel, and the more calories you burn, the more fuel your body has at its disposal.

What it all comes down to is that if you have a higher metabolic rate, your body can more quickly and efficiently convert calories into energy, therefore providing you with more energy.

This sustained increase of available energy therefore translates to increased physical performance. In simplest terms, if you have more energy, or more specifically, if your cells and organs have more energy at their disposal, they can function at an increased level for a prolonged period of time.

The more energy your cells, organs, and muscles get, the better they can perform, which directly translates to increased endurance and strength.

Here we actually have two individual studies, both of which show that NMN supplementation improves physical muscle strength. As well, here we have an interesting study that shows that NMN supplementation over a prolonged time results in a whopping 50% increase in muscular and physical endurance.

On that note, as we've already established above, NMN supplementation can help increase overall vascularity and blood flow. If you have more blood flow into your muscles, this also leads to increased muscular endurance. When you use your muscles vigorously, lactic acid builds up, which is what causes that burning sensation and makes your muscles feel tired.

However, the more blood and oxygen you have fallen into your muscles, the less that lactic acid builds up, and the faster it can break down, therefore allowing for greater endurance.

On that same note, the more blood you have flowing to your muscles, the more oxygen and protein they get, which in turn leads to them healing much faster after bouts of exercise.

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Metabolic Maintenance: NMN's Influence on Metabolic Health

As we have already established above, NMN helps to increase metabolism by increasing the functionality of the mitochondria in your body. Once again, mitochondria are in part responsible for turning fuel into the energy your body needs to function and help your cells heal, grow, and multiply faster.

Just to reiterate, NMN is shown to help increase the overall metabolic rate, resulting in you burning more calories in a shorter period of time. The more calories you burn in any given amount of time, the less of those calories will be stored in your body, generally in the form of body fat.

Furthermore, if you are in a calorie deficit, this means that your body is receiving fewer calories than it needs to function.

If your body is in a calorie deficit and it's not getting the fuel it needs to perform its regular functions, it then has to take that fuel from another source, which in this case is your fat reserves.

Therefore, if NMN helps increase your metabolic rate to the point where you burn more calories than you consume, it should also help with weight loss goals.

Here we have two studies that prove as much, with this one showing that NMN supplementation caused a reduction in fat mass in rats, and here we have a human trial that showed that 1,000-milligram doses of NMN daily helped to significantly reduce body weight, while also reducing blood pressure and cholesterol.

Yes, that is right, and NMN supplementation can even help reduce total cholesterol levels.

However, there's more to it than that because it's also shown that NMN supplementation can help improve insulin function and decrease blood sugar levels.

Not only is this ideal for weight loss goals, but it may also assist in diabetes management and prevention. Here's a study of diabetic males that suggests that NMN improves diabetic-impaired glucose tolerance. 

This study shows how NMM supplementation can help to improve insulin levels.

The Anti-Aging Elixir: How NMN Slows the Aging Process

OK, so we already covered exactly how NMN supplementation helps prevent age-related decline further above, particularly in terms of cellular and organ decline and cognitive decline. Above, we also mentioned evidence of how NMN and supplementation can help reverse or at least slow down the aging of the skin.

To summarize what was discussed above, NMN supplementation helps to improve mitochondrial function in the body, which in turn helps all of your cells regenerate faster, heal faster, grow faster, and multiply faster.

The faster your cells multiply and heal, the longer they'll stay healthy and functional, and in essence, this prevents you from aging. Of course, it doesn't literally prevent you from aging because time never stops passing, but it can slow down the effect of time on your body.

As we've discussed above, NMN helps your organs and other parts of your body heal faster and stay in better health for longer. It helps with neurological and cognitive decline, has cardiovascular benefits, and is good for energy metabolism, physical strength, endurance, and more. Overall, this absolutely leads to improved quality of life and longevity.

To really hammer this home, here is a scientific article that states that “In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety.”

Navigating the Use of NMN Supplements: Safety and Dosage Insights

One can safely assume that the more NMN you take, the bigger the benefits that you will reap, which is quite likely. However, the issue of side effects arises here, as too much of anything is not good for the human body, which also applies to NMN.

Now, the jury is still somewhat out on this one, as there are a variety of studies that all show slightly different results.

For instance, here we have a study that showed that there were no side effects or negative consequences when taking doses of NMN up to 500 milligrams per day.

Here is a study that showed no harm was done when taking 900-milligram doses every day. Here, we have a study that suggests that there were no problems when taking doses of up to 1200 milligrams on a daily basis.

With that being said, although there is still more research required on this front, most of the studies so far show that there is no toxicity to human beings when taking NMN supplements on a regular basis.

However, how much is needed to reap the various benefits remains a mystery.

There do, however, appear to be some mild side effects associated with regular NMN supplementation, including some mild upper respiratory health issues, abdominal pain, gas, and diarrhea.

Whatever the case may be, before you start any kind of new supplement, it's always recommended that you consult with an expert healthcare practitioner.

You need to talk to someone who knows your own medical situation as well as someone who also knows a thing or two about NMN. If you have any kind of specific health concerns, consulting a doctor before you start a new supplement is absolutely necessary.

This is especially the case if you are already aging and suffering from pre-existing health conditions.

Final Thoughts

As can be seen from all of the evidence presented above, NMN supplementation has some very real benefits, including, but not limited to, decreasing age-related decline, anti-aging effects, neurological and cognitive benefits, cardiovascular benefits, metabolic and weight loss benefits, and so much more. 

The simple reality is that an NMN supplement might just be your new best friend. That said, be sure to consult a healthcare professional before starting any new supplement regimen.

NMN Supplement Benefits: FAQs

What is the Recommended Daily Dosage of NMN Supplements?

Although at this time there is no one official recommendation, as can be seen above, it is likely that taking up to 1,200 milligrams of NMN per day should be safe.

Can NMN Supplements Interact with Other Medications?

At this time, it does not appear as though NMN supplements have interactions with other medications.

How Soon Can I Expect to See Results After Taking NMN Supplements?

Although individual results may vary, you should start seeing effects within about two or three weeks of first taking NMN supplements.

Are There Any Side Effects Associated with NMN Supplements?

Some common side effects associated with NMN supplements include gastrointestinal upset, gas, and diarrhea.

Can NMN Supplements be Taken During Pregnancy or While Breastfeeding?

At this time, there is not sufficient evidence to make a recommendation on this front, and therefore, we cannot recommend that pregnant or breastfeeding women take NMN supplements.